{"product_id":"acupan-20mg-2ml-solution-for-injection-5s","title":"Acupan 20mg\/2ml Vials 5's","description":"\u003cp class=\"p1\"\u003e\u003cb\u003eAcupan 20mg\/2ml solution for injection\u003c\/b\u003e is a prescription-only, centrally acting, non-opioid analgesic containing the active ingredient nefopam hydrochloride. This specific pack size contains \u003cb\u003e5 glass ampoules\u003c\/b\u003e, each loaded with 2ml of solution.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003eIt is used primarily for the \u003cb\u003eshort-term symptomatic relief of acute painful conditions\u003c\/b\u003e, most notably postoperative pain following surgery. Unlike morphine, Acupan is a non-morphinic agent, meaning it does not cause respiratory depression or slow down intestinal transit. However, a risk of drug dependency does exist, and it is strictly contraindicated for chronic pain management.\u003c\/p\u003e\n\u003cp class=\"p3\"\u003e\u003cb\u003eClinical Overview \u0026amp; Mechanics\u003c\/b\u003e\u003c\/p\u003e\n\u003cul class=\"ul1\"\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eActive Composition:\u003c\/b\u003e Each 2 ml glass ampoule contains \u003cb\u003e20 mg of nefopam hydrochloride\u003c\/b\u003e. Excipients include disodium phosphate, sodium phosphate, and water for injection. \u003c\/li\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eMechanism of Action:\u003c\/b\u003e Nefopam works within the central nervous system by inhibiting the reuptake of catecholamines (dopamine, norepinephrine) and serotonin. It also features unique anti-hyperalgesic properties and helps mitigate post-operative shivering\/chills.\u003c\/li\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eKey Distinctions:\u003c\/b\u003e It is completely unrelated to traditional NSAIDs or opioid medications. Because it is distinct from opioids, a sudden switch from morphine to Acupan in opioid-dependent individuals can trigger an acute withdrawal syndrome.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"p3\"\u003e\u003cb\u003eAdministration \u0026amp; Dosage Protocols\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003eAcupan must be administered by a trained healthcare professional using one of two distinct clinical pathways:\u003c\/p\u003e\n\u003cul class=\"ul1\"\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eIntramuscular (IM) Route:\u003c\/b\u003e Administered via a deep intramuscular injection. The standard dosage is 20 mg per injection. If clinical pain persists, it may be repeated every 6 hours as needed. The total daily dose must never exceed \u003cb\u003e120 mg in a 24-hour period\u003c\/b\u003e.\u003c\/li\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eIntravenous (IV) Route:\u003c\/b\u003e Administered strictly via a slow intravenous infusion lasting \u003cb\u003eat least 15 minutes\u003c\/b\u003e. The injection can be diluted using standard perfusion fluids like isotonic sodium chloride (saline) or glucose\/dextrose solution. It can be repeated every 4 hours if necessary, keeping within the \u003cb\u003e120 mg daily ceiling\u003c\/b\u003e.\u003c\/li\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eCritical Protocol:\u003c\/b\u003e The patient \u003cb\u003emust remain completely flat on their back (recumbent position)\u003c\/b\u003e during and for 15 to 20 minutes after IV or IM administration to safely prevent orthostatic side effects like severe dizziness, nausea, or fainting.\u003c\/li\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eMixing Restriction:\u003c\/b\u003e Medical personnel should avoid mixing Acupan with any other injectable medications in the same syringe or infusion setup.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"p3\"\u003e\u003cb\u003eAbsolute Contraindications\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003eThis medication \u003cb\u003emust not\u003c\/b\u003e be administered under any circumstances to individuals presenting with:\u003c\/p\u003e\n\u003cul class=\"ul1\"\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eAge Limits:\u003c\/b\u003e Children and teenagers under the \u003cb\u003eage of 15\u003c\/b\u003e.\u003c\/li\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eHypersensitivity:\u003c\/b\u003e A known allergy or hypersensitivity to nefopam hydrochloride or the phosphate-based excipients.\u003c\/li\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eNeurological History:\u003c\/b\u003e Active convulsions or a documented prior history of seizure disorders.\u003c\/li\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eUrological Risks:\u003c\/b\u003e A high risk of urinary retention stemming from urethroprostatic or prostate-related clinical conditions.\u003c\/li\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eOcular Risks:\u003c\/b\u003e A risk of acute angle-closure glaucoma (severe pressure buildup inside the eye structures).\u003c\/li\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eCardiovascular History:\u003c\/b\u003e Recent myocardial infarction (heart attack). Concurrent use with Monoamine Oxidase Inhibitors (MAOIs) is also contraindicated. \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"p3\"\u003e\u003cb\u003eSide Effects \u0026amp; Clinical Cautions\u003c\/b\u003e\u003c\/p\u003e\n\u003cul class=\"ul1\"\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eCommon Side Effects:\u003c\/b\u003e Dizziness, significant sweating, nausea, vomiting, drowsiness, and dry mouth.\u003c\/li\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eAnticholinergic \u0026amp; Sympathomimetic Responses:\u003c\/b\u003e Can cause tachycardia (elevated heart rate), palpitations, blurred vision, and urinary retention.\u003c\/li\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eSpecial Precautions:\u003c\/b\u003e Extreme caution and dosage adjustments are required for individuals suffering from \u003cb\u003ehepatic (liver) insufficiency\u003c\/b\u003e or \u003cb\u003erenal (kidney) impairment\u003c\/b\u003e due to the increased threat of drug accumulation. Due to its severe heart-accelerating and anticholinergic profiles, it is generally discouraged for elderly populations and those with advanced cardiovascular disease.\u003c\/li\u003e\n\u003cli class=\"li1\"\u003e\n\u003cb\u003eSubstance Interactions:\u003c\/b\u003e Alcohol must be completely avoided during treatment, as it drastically amplifies the sedative and central nervous system side effects of the medication.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Optum Health Pharmacy","offers":[{"title":"Default Title","offer_id":67652355064108,"sku":null,"price":2025.0,"currency_code":"KES","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0844\/6895\/7484\/files\/prescription-required.png?v=1745497922","url":"https:\/\/optumhealthpharmacy.africa\/products\/acupan-20mg-2ml-solution-for-injection-5s","provider":"Optum Health Pharmacy","version":"1.0","type":"link"}