{"product_id":"aprovasc-150mg-5mg-tabs-28s","title":"Aprovasc 150mg\/5mg Tabs 28's","description":"\u003cp\u003eAprovasc® film coated tablet 150 mg\/5 mg. Each tablet contains 150 mg irbesartan and 5 mg of amlodipine\u003cbr\u003e\u003cbr\u003eAprovasc® is indicated in the treatment of hypertension in adult patients in whom blood pressure is not\u003cbr\u003eadequately controlled on irbesartan or amlodipine monotherapy.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eDosage\u003cbr\u003eThe usual initial and maintenance dose of Aprovasc® is one tablet per day. Aprovasc® can be administered with or without food.\u003cbr\u003eAprovasc® should be administered in patients whose blood pressure is not adequately controlled on\u003cbr\u003emonotherapy with irbesartan or amlodipine or for continuation of therapy for patients receiving irbesartan and amlodipine as separate tablets.\u003c\/p\u003e\n\u003cp\u003eDose should be determined on a case-by-case basis, based on patient response to therapy with the individual components and the desired antihypertensive response. The maximum recommended dose with Aprovasc® is 300 mg\/10 mg per day.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eTreatment should be adjusted based on blood pressure response.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003ePediatric patients: The safety and efficacy of Aprovasc® has not been established in this population.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eElderly patients and patients with impaired renal function: In general, no dosage reduction is necessary in elderly patients or patients with impaired renal function (regardless of the degree of impairment).\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003ePatients with impaired hepatic function: As the medicinal product contains amlodipine, Aprovasc® should be administered with caution in these patients\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eIrbesartan is a specific antagonist of angiotensin II receptor (AT1 subtype). Angiotensin\u003cbr\u003eII is an important component of the renin-angiotensin system involved in the pathophysiology of hypertension and sodium homeostasis. Irbesartan does not require metabolic activation for its action.\u003cbr\u003eIrbesartan blocks the potent vasoconstrictor and aldosterone-secreting effects of angiotensin II, by selective antagonism of angiotensin II receptors (AT1 subtype) localized in vascular smooth muscle cells and in the adrenal cortex.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eAmlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slowchannel blocker) that inhibits the entry of calcium ions and the transmembrane influx of these ions into both cardiac smooth muscle and vascular smooth muscle. The mechanism of the antihypertensive action of amlodipine is due to a direct relaxant effect on the vascular smooth muscle. The precise mechanism by which amlodipine alleviates angina symptoms has not been determined, however, amlodipine reduces the total ischemic burden through the following two actions:\u003cbr\u003e1) Amlodipine dilates the peripheral arterioles and thus reduces the total peripheral resistance (after load)\u003cbr\u003eagainst which the heart works. Since the heart rate remains stable, this heart discharge reduces myocardial energy consumption and oxygen requirements;\u003cbr\u003e2) Amlodipine mechanism of action probably involves also dilatation of the main arteries and coronary arterioles, both in ischemia and normal areas. This dilatation increases the oxygen supply to the myocardium in patients with coronary artery spasm (Prinzmetal's or variant angina).\u003c\/p\u003e","brand":"Optum Health Pharmacy","offers":[{"title":"Default Title","offer_id":50750183342380,"sku":null,"price":4575.0,"currency_code":"KES","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0844\/6895\/7484\/files\/prescription-required.png?v=1745497922","url":"https:\/\/optumhealthpharmacy.africa\/products\/aprovasc-150mg-5mg-tabs-28s","provider":"Optum Health Pharmacy","version":"1.0","type":"link"}